Bio Inspire is executed in a consortium of careful selected partners. In the multi-disciplinary field of bone regeneration partners are selected with a high reputation in a set of complementary expertises.
Bone therapeutics SA
Bone Therapeutics is a regenerative therapy company specializing in addressing unmet medical needs in the field of orthopaedics via a minimally invasive approach. Utilizing the company's unique knowledge of the bone physiology, and long-standing expertise in cell therapy and cell transplantation, Bone Therapeutics has created a fully integrated business with an advanced product pipeline comprising novel regenerative products, tailored in-house production methods and minimally invasive treatment techniques.
Bone Therapeutics' autologous product, PREOB®, is currently in phase III clinical trials for the treatment of osteonecrosis and non-union fractures as well as in a phase II trial for severe osteoporosis. Bone Therapeurtics is also developing an allogeneic bone cell product ALLOB®, which is in a phase II clinical trial for delayed union fractures. All of Bone Therapeutics' regenerative products are manufactured to the highest GMP standards and protected by a rich IP estate.
Erasmus Medical CenterThe core activities of Erasmus MC are patient care, education and research. At the hospital, patient care is the core activity; the core activities at the medical faculty are education and research. Every medical department has an educational purpose and also conducts scientific research. There are approximately 12,000 employees and 2500 medical students. Erasmus MC's research covers the entire spectrum from fundamental non-clinical research to patient related research and has a broad field of interests that stretches from illness to health, and from individual to community healthcare.
For BioInspire, research groups from the departments of Orthopaedics & Otorhinolaryngology (lead by Prof. dr. Gerjo van Osch), Internal Medicine (lead by Prof. dr. Hans van Leeuwen) and Oral maxillofacial Surgery (lead by dr. Eric Farrell) will collaborate. The focus of these research group lies on anabolic and catabolic processes in bone and cartilage metabolism in degenerative diseases such as osteoarthritis and osteoporosis as well as ways to repair lesions where we apply principles of tissue engineering and regenerative medicine. We have all standard equipment necessary for cell and tissue culture, viral transfections, histology, biochemistry and molecular biology available in our own laboratories.
Fraunhofer InstituteAs a non-profit organisation, the Fraunhofer-Gesellschaft undertakes applied research of direct utility to private and public enterprises and of wide benefit to society. The Fraunhofer IGB is one of 66 institutes and independent research units. The competences comprise interfacial engineering and membrane technology as well as biotechnology, cell biology and bioprocess engineering.
Fujifilm Manufacturing B.V.
Fujifilm is world's largest imaging company. Many of Fujifilm's new products find their roots in the company's original product: photographic film. However, our activities nowadays extend over a much wider area than photographic film. Today more than 70% of the products sold by Fujifilm have been developed over the last decade. These include products in medical and life science applications.
Fujifilm developed a recombinant peptide based on collagen I (Cellnest®). This biomaterial is enriched with RGD to enhance cell binding properties. In Bio Inspire Fujifilm's recombinant peptide will be used to design a scaffold that facilitates bio-mineralisation and cell ingrowth.
ISTEC - CNRThe Institute of Science and Technology for Ceramics (ISTEC-CNR) is an interdisciplinary research institute for the study of advanced materials in the biomedical, energy, aerospace and environmental field. The Biomaterials and Bio-Hybrid Composite Group counts 14 senior and young investigators with 25 years experience in the field of calcium phosphate-based materials. These include ceramics and bio-hybrid composites for biomedical applications, particularly for regeneration of hard and soft human tissues.
ISTEC-CNR has facilities for synthesis of ceramic and hybrid biomaterials and scaffolds, as well as for extensive chemical, physical, thermal, morphological and mechanical characterisation. The scientific activities of ISTEC-CNR focus, among others, on:
- Set up of biologically inspired synthesis processes, in particular biomineralisation, to obtain 3D porous constructs with specific functions (e.g. bone regeneration).
- Multi-layer hybrid scaffolds for regeneration of multifunctional anatomical areas, in particular the articular regions
- Development of composite biopolymeric matrices able to assist biomineralisation
- Cross-linking mechanisms
MedicyteUnfortunately, the bankruptcy of Medicyte forced this project partner to leave the consortium early at M24 (1 Oct 2015) of the project. Medicyte was involved in WP4 only and responsible for one fellow. This fellow can continue his work at Fraunhofer for his remaining training period of 18M. There will be no impact on his research and training programme.
Alma Mater Studiorum - UNIBOThe University of Bologna was probably the first university in the Western world. Its history is one of great thinkers in science and the humanities, making it an indispensable point of reference in the panorama of European culture. The insitution that we today call the University began to shape in Bologna at the end of the eleventh century, when masters of Grammar, Rhetoric and Logic began to devote themselves to the law. In the nineteenth century a committee of historians, led by Giosuè Carducci, attributed the birth of the University to the year 1088.
The reorganisation of the university system, the presence throughout the territory, the international outlook, the research, the programme catalogue, the information services: in these and many other areas, today the ALma Mater Studiorum paves the way for innovation.